Endocrine Abstracts

Introduction. Lipocortin-1 (annexin-1 and p35) is a 37-kDa Ca2+-dependant membrane-binding protein that hasanti-inflammatory, anti-mitotic and anti-proliferative properties.With these properties in mind it was hypothesised that lipocortin-1 may have an important role in the endometrium. Therefore, the aim ofthis study was to determine the distribution of lipocortin-1 in normal and abnormal endometrial tissue.Methods. Formalin fixed paraffin embedded sect...

Somatostatin (sst) acts via five G-protein-coupled receptors (sstr) that effect angiogenesis, cell proliferation and apoptosis. We have reported the expression of these receptors in normal endometrium and in this study we have extended those observations to the expression of sstr subtypes 1, 2, 3, and 5 within hyperplastic and neoplastic endometrium using immunohistochemistry. METHOD The avidin-biotin-peroxidase method was used to immunostain formalin-fixed, paraffin-embedded ...

Lipocortin 1 (LC1) is a well-characterized anti-inflammatory, -anti mitotic and anti-proliferative member of a structurally related family of Ca2+ and phospholipid-binding proteins. LC1 is readily detectable in the neuroendocrine system by Western blot analysis, ELISA, and immunohistochemistry (1). In these tissues, glucocorticoids regulate both the expression and subcellular distribution of LC1. Other studies have also demonstrated the presence of LC1 in endometrium tissue th...